ChondroFiller®liquidSupplied in the UK by Actomed

Product information

Composition, indications, contraindications and technique.

Composition, intended purpose, indications, contraindications, handling, storage and arthroscopic technique for ChondroFiller® liquid.

EvidenceTraining and ordering
ChondroFiller liquid 1.0 ml and 2.3 ml packs with a pre-filled dual-chamber syringe resting on them

Composition

A cell-free, two-component collagen matrix.

A cell-free, two-component type I collagen matrix of animal origin (rat tail tendon), as described in the published literature, supplied as a collagen solution and a neutralising solution that are mixed through an adapter at the point of use and form a stable gel in the prepared defect within minutes.1

Intended purpose and indications

Grade III to IV cartilage damage in the knee, hip, shoulder, ankle and hand.

The manufacturer's patient information states: ‘The application is intended to be used for filling clearly delimited cartilage damage up to grade IV in joints such as the knee, hip, shoulder and ankle as well as in partial cartilage injuries, subchondral and osteochondral defects. The implant offers the patient's own cells the opportunity to migrate into the matrix for the associated tissue regeneration. At the same time it serves as protection against further cartilage degeneration. Use in other parts of the body, such as auricle or breast, is not permitted.’3

  • Grade III to IV cartilage damage in the knee, hip, shoulder, ankle or the small joints of the hand.6

  • Defect size up to 3 cm², per the manufacturer’s product page.6

Contraindications

Per the instructions for use.

  • Contraindications are listed in the instructions for use supplied with each pack.2

  • Known hypersensitivity to collagen.3

Warnings, precautions, handling and storage

Hypersensitivity, and how the matrix is handled.

The manufacturer states: 'In rare cases, hypersensitivity reactions to collagen such as allergic or inflammatory reactions can occur. There are no known complications caused by the implant of ChondroFiller® liquid.' No adverse events were reported in a multicentre trial of 23 randomised patients, 13 of whom received ChondroFiller. Report any suspected product quality or safety issue to Actomed, the UK Responsible Person.3,4

  • ChondroFiller liquid is supplied frozen, and thawed and warmed before use as described in the published technique papers.4

  • The same defrost-and-warm handling is described in a separately published hip arthroscopy technique paper.1

  • The collagen is type I collagen of animal origin (rat tail tendon), as described in the published literature.1

  • A published multicentre trial describes the material as an 8 mg per mL type I collagen gel.4

  • Thaw within 24 hours at 2 to 10 °C, or in about 30 minutes at 25 to 30 °C; warm to 30 to 33 °C immediately before use, for less than 15 minutes. Longer warming, or any temperature above 33 °C, damages the collagen irreversibly, per the manufacturer’s surgical technique guide.7

  • Fill the defect in one continuous pass in under 20 seconds and keep the limb still for the 3 to 5 minute stabilisation, per the manufacturer’s surgical technique guide.7

  • Storage temperature, shelf life and preparation temperature are specified in the instructions for use supplied with each pack.2

Technique

Placed into the defect during keyhole surgery, under direct vision.

ChondroFiller is placed into a prepared cartilage defect during keyhole (arthroscopic) surgery, under direct vision. This is the method described by the manufacturer.2

  1. 01

    Illustration of identifying a cartilage defect during arthroscopic surgery

    Identify

    The surgeon identifies and prepares the cartilage defect during arthroscopic (keyhole) surgery.2

  2. 02

    Illustration of preparing a cartilage defect before implantation

    Prepare

    A needle-and-curette technique for preparing a hip chondral defect before implantation has been described in the published literature.1

  3. 03

    Illustration of ChondroFiller being applied into a prepared cartilage defect

    Fill

    ChondroFiller liquid is supplied as a collagen solution and a neutralising solution in a dual-chamber syringe, mixed through an adapter at the point of use. The mixed matrix is applied through the applicator into the prepared defect.5

  4. 04

    Illustration of the applied matrix setting into a gel in the joint

    Set

    The matrix forms a stable gel in the defect within a few minutes.5

Arthroscopic view of a prepared cartilage defect
Defect preparation, arthroscopic view
Arthroscopic view of the matrix applied into the prepared defect
Matrix applied into the prepared defect
MRI follow-up scan of a knee joint, manufacturer material, view 1
MRI follow-up, view 1
MRI follow-up scan of a knee joint, manufacturer material, view 2
MRI follow-up, view 2

Formats

Available pack sizes.

ChondroFiller formats, presentation and setting time.
PropertyValue
Formats1.0 ml, 1.5 ml, 2.3 ml5
PresentationSupplied as a ready-to-use dual-chamber syringe: a collagen solution and a neutralising solution mixed through an adapter at the point of application.5
Setting timeThe mixed matrix hardens into a hydrogel in approximately 3 to 5 minutes, per the manufacturer.5

References

  1. 1.Perez-Carro L, Mendoza Alejo PR, Gutierrez Castanedo G, Menendez Solana G, Fernandez Divar JA, Galindo Rubin P, Alfonso Fernandez A. Hip Chondral Defects: Arthroscopic Treatment With the Needle and Curette Technique and ChondroFiller. Arthroscopy Techniques, 10(7):e1669-e1675, 2021. View DOI
  2. 2.Meidrix Biomedicals GmbH. ChondroFiller® liquid instructions for use. Meidrix Biomedicals GmbH, 2026. View source
  3. 3.Meidrix Biomedicals GmbH. ChondroFiller® liquid patient education leaflet. Manufacturer publication, 2022. View source
  4. 4.Schneider U. Controlled, randomized multicenter study to compare compatibility and safety of ChondroFiller liquid (cell free 2-component collagen gel) with microfracturing of patients with focal cartilage defects of the knee joint. Video Journal of Orthopedics Surgery, 1:1-8, 2016. View DOI
  5. 5.Meidrix Biomedicals GmbH. ChondroFiller® liquid overview brochure. Manufacturer publication, 2024. View source
  6. 6.Meidrix Biomedicals GmbH. ChondroFiller® liquid product page. Meidrix Biomedicals GmbH, 2026. View source
  7. 7.Meidrix Biomedicals GmbH. ChondroFiller® liquid surgical technique. Manufacturer publication, 2022. View source

Continue to the evidence, or arrange training and ordering.

Published references and manufacturer documents, or how UK clinics order ChondroFiller and arrange training.

EvidenceTraining and ordering